According to a recent report by RAND Corporation, nearly 12% of Americans have utilized GLP-1 drugs for weight loss, with approximately one-fifth of women aged 50 to 64 participating in this trend.
Overview of GLP-1 Drug Usage
In a survey conducted with a nationally representative sample of 8,793 Americans, researchers found that 11.8% reported having used GLP-1 agonists for weight management. Additionally, 14% expressed an interest in utilizing these medications in the future, while 74% indicated they do not intend to take them.
Common Side Effects
Among individuals who have used GLP-1 medications, nearly half reported experiencing nausea, while approximately one-third experienced diarrhea—these being the most frequently reported side effects associated with the drugs.
Growth in Prescriptions
This report represents the most extensive survey to date examining the usage patterns of GLP-1 medications, which have transformed weight loss management in recent years. Notably, since 2020, the number of prescriptions for these drugs has more than tripled, spurred by emerging studies that demonstrate their efficacy in facilitating significant weight loss.
Survey Methodology
The RAND researchers carried out this survey via the RAND American Life Panel, collecting responses during April and May of 2025. This panel consists of approximately 11,000 active participants aged 12 and older, regularly interviewed to gather comprehensive data.
Demographic Insights
The findings reveal that usage of GLP-1 drugs is most prevalent among individuals aged 50 to 64, particularly among women in this age group. Conversely, in the cohort aged 65 and older, men tend to use GLP-1 drugs slightly more frequently than women. Among individuals aged 30 to 49, women are more than twice as likely to have utilized these medications compared to their male counterparts.
Report Availability
The report titled “New Weight Loss Drugs: GLP-1 Agonist Use and Side Effects in the United States” can be accessed at www.rand.org. The authors of the report include Robert Bozick, Shannon Donofry, and Katherine M. Rancaño. This publication marks the first in a series of forthcoming brief reports that will present key findings from surveys conducted through the RAND American Life Panel.
Institutional Overview
The RAND Education and Labor division is committed to enhancing education and expanding economic opportunities for all through rigorous research and analysis.
Key Health Takeaway
The increasing use of GLP-1 medications highlights a growing trend in weight loss management among Americans. While the medications show promise, potential users should be aware of common side effects and consult healthcare professionals before starting any new treatment regimen.
